Taming the ABO barrier in transplantation

摘要

In this issue of Blood, Tazawa et al demonstrate that invariant natural killer T (iNKT) cells play a critical role in the production of antibodies against the blood group A antigen. Interrupting iNKT cell function with an anti-CD1d antibody prevents anti-A antibody formation, revealing a potential therapeutic target for ABO-incompatible transplantations.