In silico epitope (T-228) rabies virus vaccine.

摘要

Accession FJ979833 was used to extract human epitopes from rabies virus glycoprotein database. Strongest binders with MHC molecules were determined by artificial neural network and stabilized matrix methods with highest scores subjected to clustal W alignment for conservancy. An epitope from position 228-236 (T-228) was identified as a novel T cell epitope revealing good MHC class I binding, processing and conservation in known rabies viruses. The findings suggest that it may be possible to generatea synthetic peptide vaccine against rabies but further research on G protein is required, including a search for additional linear epitopes.