Amino acid sequence analysis in patients with chronic HCV genotype 1b infection during pegylated interferon-alpha 2a and ribavirin therapy

摘要

Background: Amino acid variations in several HCV genomic regions have been reported to be associated with response to interferon (IFN)-alpha plus ribavirin (RBV) combination therapy. However, the results remain controversial. In this study, we further investigated the amino acid variation of full-length HCV genome and its correlation to the response to pegylated interferon (PEG-IFN)-alpha 2a and RBV combination therapy in patients with HCV genotype 1b (HCV-1b).