Gentamicin Loaded PLGA based Biodegradable Material for Controlled Drug Delivery

摘要

In wound care there is room for delivering antibiotic drug at wound site to avoid or control the infections. This current work is about preparation and evaluation of poly(lactic-co-glycolic acid) (PLGA) and poly(caprolactone) (PCL) based, gentamicin (GE) loaded biodegradable material to get optimum drug at site for antibacterial action. Drug release, degradation behav- iour and tensile properties of prepared bio-material are studied up to 42 days. Drug release in in-vitro release testing (IVRT) was studied by UV absorbance of receptor solution. Physical characteristics such as molecular weight, tensile strength and morphology of bio-material are carried out as a function of time during IVRT studies. The employed bio-material releases 3.4 μg/g/h drug with a steady decrease in tensile strength and PLGA molecular weight. In this manuscript it is demonstrate that PLGA and PCL based bio-material will release the loaded drug in controlled manner with simultaneous degradation.