FORMULATION.AND.EVALUATION.OF.BIOPOLYMER.BASED.TRANSDERMAL.DRUG.DELIVERY

摘要

The.aim.of.the.present.study.was.to.formulate.transdermal.films.loaded.with.Ketoprofen.(KF)..Transdermal.films.were.prepared.by.using.sodium.alginate. (SA).and.xanthan. gum.(XG).as. biopolymers.by.varying.the.blend.ratios.viz.,.10:0,.8:2,.6:4,.4:6.and.2:8.(w/w.%).through.solution.casting.method..The.drug.loaded.membranes.were.evaluated.for.thickness,.tensile.behaviors,.content.uniformity,.transdermal.permeation.of.KF.through.rat.abdominal. skin.was.determined. by. Franz.diffusion. cell.. In. vitro. skin. permeation.profile.of.optimized. formulation.was.compared. with. that. of.KF.conventional. gel.. Carrageenen. induced. rat. paw. edema. model. was. used. to. investigate. their. in. vivo. performances.. Ketoprofen. was. found. to. be.compatible.and.stable. with.the.prepared. formulation. as. confirmed. by.Fourier. transform.infrared.spectroscopy.(FTIR).and.Differential. Scanning.Calorimetry. (DSC),. studies.. In-vitro.release. studies. revels. effectiveness. after. 24. h. when. compared.with. the. conventional. gel.. The. study. results.suggest.that.biopolymer.based.transdermal.films.are.potential.vehicles.for.improved.transdermal.delivery.of.KF.for.effective.therapy