Copper-Catalyzed One-Pot Synthesis of Pyrrolo[1,2-a] quinoxaline Derivatives from 1-(2-Aminophenyl)-pyrroles and Aldehydes

摘要

A facile and highly efficient copper-catalyzed strategy has been developed for the synthesis of pyrrolo[1,2-a]quinoxalines from 1-(2-aminophenyl)-pyrroles and aldehydes at room temperature.This reaction proceeds via imine formation,cyclisation,and oxidation in one-pot.This strategy provides a facile and rapid access to pyrrolo[1,2-a]quinoxalines in good to high yields under mild conditions.This process has several advantages,such as simple reaction procedure,readily available starting materials,low catalyst loading,easy product isolation,broad substrate scope,high functional group tolerance,and gram-scale synthesis.