机译:设计和合成4-(2,3-二氢-1H-苯并[D] Pyrrolo [1,2-A]咪唑-7-基)-N-(5-(哌嗪-1-基甲基)吡啶-2- Y1)嘧啶-2-胺作为高效和选择性细胞周期蛋白依赖性激酶4和6抑制剂以及结构 - 活性关系的发现
Beijing Univ Technol Dept Chem &
Chem Engn Beijing Key Lab Green Catalysis &
Separat Beijing;
Gan &
Lee Pharmaceut R&
D 8 Jingsheng North 3rd St Beijing 101102 Peoples R China;
Gan &
Lee Pharmaceut R&
D 8 Jingsheng North 3rd St Beijing 101102 Peoples R China;
Gan &
Lee Pharmaceut R&
D 8 Jingsheng North 3rd St Beijing 101102 Peoples R China;
Gan &
Lee Pharmaceut R&
D 8 Jingsheng North 3rd St Beijing 101102 Peoples R China;
Gan &
Lee Pharmaceut R&
D 8 Jingsheng North 3rd St Beijing 101102 Peoples R China;
Beijing Univ Technol Dept Chem &
Chem Engn Beijing Key Lab Green Catalysis &
Separat Beijing;
Gan &
Lee Pharmaceut R&
D 8 Jingsheng North 3rd St Beijing 101102 Peoples R China;
Beijing Univ Technol Dept Chem &
Chem Engn Beijing Key Lab Green Catalysis &
Separat Beijing;
Beijing Univ Technol Dept Chem &
Chem Engn Beijing Key Lab Green Catalysis &
Separat Beijing;
Beijing Handian Pharmaceut Co Ltd Kuntai Int Bldg Beijing 100020 Peoples R China;
CDK4/6 inhibitors; CDK1; Abemaciclib; Potent; Selective; Anticancer;
机译:设计和合成4-(2,3-二氢-1H-苯并[D] Pyrrolo [1,2-A]咪唑-7-基)-N-(5-(哌嗪-1-基甲基)吡啶-2- Y1)嘧啶-2-胺作为高效和选择性细胞周期蛋白依赖性激酶4和6抑制剂以及结构 - 活性关系的发现
机译:高活性,选择性强,脑渗透剂3- [4-(吗啉-4-基)-7H-吡咯并[2,3-d]嘧啶-5-基]苄腈(PF-06447475)的发现和临床前分析和体内活性LRRK2激酶抑制剂
机译:发现N-(3-(5 - ((3-丙基-4-(吗啉-4-羰基)苯基)氨基)-1-甲基-6-氧代-1,6-二氢吡啶-3-Y1)-2 - 甲基苯基)-4-(叔丁基)苯甲酰胺(CHMFL-BTK-01)作为高选择性不可逆的Bruton的酪氨酸激酶(BTK)抑制剂
机译:发现取代的4-(吡唑-4-基)-苯基苯并二恶烷-2-羧酰胺为强效和高选择性Rho激酶(ROCK-II)抑制剂
机译:新型有效口服活性选择性选择性VEGFR-2酪氨酸激酶抑制剂:N-苯基-N- {4-(4-喹啉氧基)苯基}脲的合成,结构活性关系和抗肿瘤活性