Peroxidase-Mimetic and Fenton-Like Activities of Molybdenum Oxide Quantum Dots

摘要

Molybdenum oxide nanomaterials have become a popular nanomaterial while its catalysis behavior especially the biocatalysis property is little understood,even though molybdenum has been employed as a key cofactor in several important enzymes in biological system.On the basis of these,the Fenton and peroxidase-like property of molybdenum oxide quantum dots(MoOx QDs)with mixed valence state was carefully investigated using tetramethylbenzidine(TMB)and methyl orange(MO)as the substrates.The results showed that MoOx QDs not only serve as a Fenton reagent,degrading MO to colorless products,but also exhibit intrinsic peroxidase-mimetic activity,oxidizing TMB to the oxidized state oxTMB.The catalysis mechanism of MoOx QDs is that MoOx QDs can facilitate the decomposition of H2O2 and a large amount of radicals was generated,leading to MO decomposing and TMB oxidizing subsequently.Inspired by the findings,a visible method was developed for sensitive and selective detection of H2O2 and glucose,and the limit of detection for H2O2 and glucose is 7.75 μM and 8.95 μM(3σ/K),respectively.Moreover,glucose content in human serum samples was successfully determined by the proposed visible method,and the results are consistent well with those obtained by handheld glucose meter,suggesting a high accuracy of the present method.