A Short and Efficient Enantioselective Synthesis of(+)-(2S,3S,5S)-epi-Muscarine

摘要

A short,efficient and novel enantioselective general approach for the synthesis of muscarine alkaloid and its application to the asymmetric synthesis of epi-muscarine from readily available(R)-PMB glycidyl ether as starting material is described.Key transformations include Sharpless asymmetric dihydroxylation(AD),regioselective epoxide ring opening and intramolecular SN2 cyclization.