NOVEL POLYMORPHIC FORMS OF ((1S,2S,3S,4R,5S))-2,3,4-(TRIS-BENZYLOXY)-5-(4-CHLORO- 3-(4-ETHOXY-BENZYL)PHENYL)-6,8-DIOXA-BICYCLO3.2.1OCT-1-YL-METHANOL

摘要

NOVEL POLYMORPHIC FORMS OF ((1S,2S,3S,4R,5S))-2,3,4-(TRIS-BENZYLOXY)-5-(4-CHLORO-3-(4-ETHOXY- BENZYL)PHENYL)-6,8-DIOXA-BICYCLO[3.2.1]OCT-1-YL-METHANOL ABSTRACT The present invention relates to novel polymorphs of ((1S,2S,3S,4R,5S))-2,3,4-(tris-benzyloxy)-5-(4-chloro-3-(4-ethoxy-benzyl)phenyl)-6,8-dioxa-bicyclo[3.2.1]oct-1-yl- methanol of formula (I) useful in the preparation of Ertugliflozin of formula (II). (I) wherein Bn refers to benzyl. The invention also relates to process for the preparation of crystalline Form G of ((1S,2S,3S,4R,5S))-2,3,4-(tris-benzyloxy)-5-(4-chloro-3-(4-ethoxy- benzyl)phenyl)-6,8-dioxa-bicyclo[3.2.1]oct-1-yl-methanol of formula (I) and characterized by X-ray powder diffraction pattern peaks selected form 5.7, 14.0, 15.6, 15.9, 17.3, 18.8, 19.7, 19.8, 23.0 ±0.2° 2. This compound of Formula I is a useful intermediate in the preparation of Ertugliflozin, which is used in the treatment of type 2 diabetes mellitus.