NEW PHARMACEUTICAL SOLID FORMS (1S, 2S, 3R, 5S) -3- 7 - (1R, 2S) -2- (3,4-DIFTORFENIL) CYCLOPROPYLAMINO -5- (PROPYLTIO) -3H- 1,2 , 3 TRIAZOLO 4,5-d PYRIMIDIN-3-IL -5- (2-HYDROXYETHOXY) CYCLOPENTAN-1,2-DIOLA

摘要

Solid State Structures (1S, 2S, 3R, 5S) -3- [7 - [(1R, 2S) -2- (3,4-difluorophenyl) cyclopropyl] -5- (propylthio) -3H- [1,2,3 ] triazolo [4,5-d] pyrimidin-3-yl] -5- (2-hydroxyethoxy) cyclopentane-1,2-diol (hereinafter referred to as ticagrelor) as a stable co-crystalline form of 3-hydroxy-2-naphthoic acids, as well as the solvate of 1,4-dioxane and methods for their preparation.