Proton pump inhibitors (PPIs) are one of the most widely used classes of medications in the United States and worldwide. This is largely because they are extremely potent suppressors of gastric acid and are therefore more effective than alternatives, such as histamine-2 receptor antagonists (H_2RAs) for common gastric acid-related problems, such as gastro-esophageal reflux disease (GERD)2 and peptic ulcer disease. Because they are so effective, PPIs are recommended by national guidelines as first-line therapy for more serious problems related to gastric acid, such as erosive esophagitis and Barrett's esophagus. They are also preferred as cotherapy with nonsteroidal anti-inflammatory drugs (NSAIDs) for patients who are at high risk of gastrointestinal complications, such as gastrointestinal bleeding.5 Finally, PPIs are also preferred to H_2RAs for maintenance therapy in patients with gastric acid hypersecretory states.
展开▼
