Enrolling Subjects by Exception From Consent Versus Proxy Consent in Trauma Care Research

摘要

Many life-threatening conditions hinder, if not preclude, the normal process of informed consent. When a patient's health condition is known and the potential for sudden deterioration in the future can be reasonably foreseen, consent may be secured in advance. This might apply, for example, to a study of an emergency treatment for sudden complications of cancer, AIDS, heart failure, or chronic lung disease. Do-not-resuscitate orders and other resuscitation instructions fit into this category. If a medical condition impairs decisionmaking but the study treatment is not time critical (eg, a new therapy for Alzheimer's disease)#