Intestinal sodium/glucose cotransporter 3 expression is epithelial and downregulated in obesity

Sotak Matus; Casselbrant Anna; Rath Eva; Zietek Tamara; Stromstedt Maria; Adingupu Damilola D.; Karlsson Daniel; Fredin Maria Fritsch; Ergang Peter; Pacha Jiri; Batorsky Anna; Alpers Charles E.; Borgeson Emma; Hansen Pernille B. L.; Ericsson Anette; Granqvist Anna Bjornson; Wallenius Ville; Fandriks Lars; Unwin Robert J.

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Intestinal sodium/glucose cotransporter 3 expression is epithelial and downregulated in obesity

机译：肠道钠/葡萄糖Cotroangerporter 3表达是上皮和下调肥胖症

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Aim: We aimed to determine whether the sodium/glucose cotransporter family member SGLT3, a proposed glucose sensor, is expressed in the intestine and/or kidney, and if its expression is altered in mouse models of obesity and in humans before and after weight-loss surgery.

机译：目的：我们旨在确定钠/葡萄糖协同转运蛋白家族成员SGLT3（一种葡萄糖传感器）是否在肠道和/或肾脏中表达，以及其在肥胖小鼠模型和减肥手术前后人类中的表达是否发生改变。

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来源
《Life sciences 》 |2021年第1期| 共11页
作者
Sotak Matus; Casselbrant Anna; Rath Eva; Zietek Tamara; Stromstedt Maria; Adingupu Damilola D.; Karlsson Daniel; Fredin Maria Fritsch; Ergang Peter; Pacha Jiri; Batorsky Anna; Alpers Charles E.; Borgeson Emma; Hansen Pernille B. L.; Ericsson Anette; Granqvist Anna Bjornson; Wallenius Ville; Fandriks Lars; Unwin Robert J.;
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作者单位

AstraZeneca BioPharmaceut R&

D Cardiovasc Renal &

Metab Biosci Res &

Early Dev Gothenburg Sweden;

Univ Gothenburg Sahlgrenska Acad Inst Clin Sci Dept Surg Gothenburg Sweden;

Tech Univ Munich Chair Nutr &

Immunol Freising Weihenstephan Germany;

Tech Univ Munich Dept Nutr Physiol Freising Weihenstephan Germany;

AstraZeneca BioPharmaceut R&

D Cardiovasc Renal &

Metab Biosci Res &

Early Dev Gothenburg Sweden;

AstraZeneca BioPharmaceut R&

D Cardiovasc Renal &

Metab Biosci Res &

Early Dev Gothenburg Sweden;

AstraZeneca BioPharmaceut R&

D Cardiovasc Renal &

Metab Biosci Res &

Early Dev Gothenburg Sweden;

AstraZeneca BioPharmaceut R&

D Cardiovasc Renal &

Metab Biosci Res &

Early Dev Gothenburg Sweden;

Czech Acad Sci Inst Physiol Prague Czech Republic;

Czech Acad Sci Inst Physiol Prague Czech Republic;

Univ Washington Sch Med Dept Pathol Seattle WA 98195 USA;

Univ Washington Sch Med Dept Pathol Seattle WA 98195 USA;

Univ Gothenburg Inst Med Dept Mol &

Clin Med Wallenberg Lab Gothenburg Sweden;

AstraZeneca BioPharmaceut R&

D Cardiovasc Renal &

Metab Biosci Res &

Early Dev Gothenburg Sweden;

AstraZeneca BioPharmaceut R&

D Cardiovasc Renal &

Metab Biosci Res &

Early Dev Gothenburg Sweden;

AstraZeneca BioPharmaceut R&

D Cardiovasc Renal &

Metab Biosci Res &

Early Dev Gothenburg Sweden;

Univ Gothenburg Sahlgrenska Acad Inst Clin Sci Dept Surg Gothenburg Sweden;

Univ Gothenburg Sahlgrenska Acad Inst Clin Sci Dept Surg Gothenburg Sweden;

AstraZeneca BioPharmaceut R&

D Cardiovasc Renal &

Metab Biosci Res &

Early Dev Gothenburg Sweden;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生 ;
关键词
High-fat diet; Leptin deficiency; Obesity; Roux-en-Y gastric bypass; SLC5A4; T2M;

机译：高脂饮食;瘦素缺乏;肥胖Roux-en-Y胃分流术;SLC5A4;T2M;

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3. Major constituents of ce:italic>Cistanche tubulosa/ce:italic>, echinacoside and acteoside, inhibit sodium-dependent glucose cotransporter 1-mediated glucose uptake by intestinal epithelial cells [J] . Hiroaki Shimada, Yuichi Urabe, Yuhei Okamoto, Journal of Functional Foods . 2017 ,第期

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4. An essential role of cAMP response element-binding protein in epidermal growth factor-mediated induction of sodium/glucose cotransporter 1 gene expression and intestinal glucose uptake [J] . Wang Chun-Wen, Chang Wen-Liang, Huang Yu-Chuan, The international journal of biochemistry and cell biology . 2015 ,第Null期

机译：cAMP反应元件结合蛋白在表皮生长因子介导的钠/葡萄糖共转运蛋白1基因表达和肠道葡萄糖摄取中的重要作用
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6. Capsaicin Induced the Upregulation of Transcriptional and Translational Expression of Glycolytic Enzymes Related to Energy Metabolism in Human Intestinal Epithelial Cells [C] . Junkyu Han, Hiroko Isoda Annual and International Meeting of the Japanese Association for Animal Cell Technology . 2010

机译：辣椒素诱导人肠上皮细胞中能量代谢相关的糖酵解酶的转录和平移表达的上调
7. Subcloning and regulation of a human intestinal sodium-phosphate cotransporter gene. [D] . Xu, Hua. 2001

机译：人肠道磷酸钠共转运蛋白基因的亚克隆和调控。
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10. Effect of Radiation on the Regulation of Sodium-Dependent Glucose Transport in LLC-PK1 Epithelial Cell Line: Possible Model for Gene Expression [R] . Moran, A., Davis, L., Hagan, M. 1986

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Intestinal sodium/glucose cotransporter 3 expression is epithelial and downregulated in obesity

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