Progress in the Medicinal Chemistry of Group III Metabotropic Glutamate Receptors

摘要

G-protein-coupled receptors (GPCRs), among the largest and most diverse protein families in mammalian genomes and accounting for 30% of all modern medicinal drugs, constitute a superf amily of proteins whose primary function is to transmit extracellular stimuli into intracellular signals. Sequence comparison of different GPCRs revealed the existence of at least six classes (A through F) [1].