首页> 外国专利> GLUTAMATE AND ITS DERIVATIVES AS MODULATORS IN THE RELEASE OF MELATONIN, REDUCING ITS CONCENTRATION IN THE EQUATION ORGANISM BY INTERACTION WITH METABOTROPIC RECEPTORS GROUP II (MGLUR3) AND IONOTROPIC RECEPTORS OF THE AMPA TYPE (GLUR1) IN MEDICINE.

GLUTAMATE AND ITS DERIVATIVES AS MODULATORS IN THE RELEASE OF MELATONIN, REDUCING ITS CONCENTRATION IN THE EQUATION ORGANISM BY INTERACTION WITH METABOTROPIC RECEPTORS GROUP II (MGLUR3) AND IONOTROPIC RECEPTORS OF THE AMPA TYPE (GLUR1) IN MEDICINE.

机译:谷氨酸及其衍生物作为褪黑激素释放的调节剂,通过与代谢受体II组(MGLUR3)和AMPA型离子受体(GLUR1)相互作用降低了其在方程式有机体中的浓度。

摘要

glutamate and its derivatives as modulators in the release of melatonin, reducing its concentration in the equine organism through interaction with group II metabotropic receptors (mglur3) and ampa (glur1) ionotropic receptors in veterinary medicine. formula compounds, salts and their derivatives, preparation processes and pharmaceutical compositions containing chemical name glutamic acid: aminoglutaric acid 2 (carboxylate anion and the glutamic acid salts that are known as glutamates) used as modulators in the release of melatonin by interaction with group ii metabotropic receptors (mglur3) and ampa (glur1) ionotropic receptors in veterinary medicine, reducing their concentration in the equine organism to reduce or eliminate reproductive seasonality in equines, as melatonin actively participates in the process of reducing production and release of the hormone gnrh which is responsible for initiating the entire pathway for the release of hormones from ovulation.
机译:谷氨酸及其衍生物作为褪黑激素释放的调节剂,通过与兽药中的II类代谢型受体(mglur3)和ampa(glur1)离子型受体相互作用,降低其在马体内的浓度。包含化学名称谷氨酸的分子式化合物,盐及其​​衍生物,制备方法和药物组合物:氨基戊二酸2(羧酸根阴离子和谷氨酸盐,称为谷氨酸盐),在与ii型代谢型相互作用的褪黑素释放中用作调节剂兽医中的受体(mglur3)和ampa(glur1)离子受体,降低它们在马生物中的浓度以减少或消除马中的繁殖季节,因为褪黑素积极参与减少gnrh激素的产生和释放的过程引发从排卵释放激素的整个途径。

著录项

  • 公开/公告号BR102019003596A2

    专利类型

  • 公开/公告日2020-10-06

    原文格式PDF

  • 申请/专利权人 GLEICE COUTINHO GUIMARAES;

    申请/专利号BR20191003596

  • 发明设计人 GLEICE COUTINHO GUIMARAES;

    申请日2019-02-21

  • 分类号A61K31/195;A61P15/18;

  • 国家 BR

  • 入库时间 2022-08-21 11:18:33

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