Impact of a tailored oral vitamin D supplementation regimen on serum 25-hydroxyvitamin D levels in early breast cancer patients: a randomized phase III study

摘要

A tailored high-dose oral vitamin D supplementation safely allows a higher percentage of the serum 25-hydroxy vitD-level normalization compared with a conventional regimen in chemotherapy-treated early breast cancer patients. As compliance to daily oral supplementation was poor in this setting, other studies are needed to confirm these data. A particular attention should be paid to oral treatment schedule.A minority of early breast cancer (EBC) patients treated with adjuvant or neoadjuvant chemotherapy have sufficient baseline vitamin D (vitD) level. This randomized phase III study assessed the safety and efficacy of a tailored, high-dose, oral vitD supplementation in restoring a normal 25-hydroxy vitD (25OHD) level in this population.