Synthesis of Cyclopropylmethyl Esters of Maleopimaric Acid and Diketocage Derivatives of Quinopimaric Acid by a Catalytic Reaction of the Corresponding Allyl Esters with Diazomethane

摘要

A Pd(acac)(2)-catalyzed reaction of allyl esters of maleopimaric and diketocage quinopimaric acid derivative with diazomethane was studied for the first time with the aim to obtain cyclopropylmethyl derivatives of the pimaric acid series as potential pharmacologically active compounds. It was shown that the reaction proceeds under mild conditions and provides the desired cyclopropylmethyl derivatives in yields of 84-98%.