Glyceraldehyde-3-phosphate dehydrogenase as a major allergen in rambutan-induced anaphylaxis.

摘要

Rambutan (Nephelium lappaceum) is a widely consumed tropical fruit in Thailand and is exported to many countries worldwide. Currently, only 1 case report of rambutan allergy has been reported, but the allergen has never been identified. This work reports 3 new cases and identification and characterization of a rambutan allergen. Three adult patients, ages 35, 49, and 53 years, had a history of multiple episodes of anaphylactic reactions within 30 minutes after ingestion of half to 2 rambutans. All patients had cutaneous (eg, angioedema, flushing, and urticaria) and respiratory (eg, rhinitis, chest tightness, stridor, and wheezing) symptoms. One patient also had cardiovascular (eg, syncope) and gastrointestinal (eg, nausea and vomiting) symptoms. Patients 1 and 3 had a history of allergic rhinitis and asthma, respectively. No patient had a history of latex allergy. There was no family history of food allergy.