Application value of nanostructured lipid carriers combined with exercise rehabilitation training in stroke patients

摘要

The morbidity and mortality of stroke are high, and nimodipine (NMD) is the only effective drug to treat ischemic dysfunction; however, the traditional delivery system exhibits highly toxic side effects and low bioavailability. The nanostructured lipid carrier (NLC) system has the advantages of improving drug solubility and bioavailability. This study analyzed the effects of NLC combined with exercise rehabilitation training in 126 stroke patients admitted to the neurology department of The First People's Hospital of Lianyungang, Affiliated to Kangda College, Nanjing Medical University from February 2018 to February 2020. The patients were divided into 2 groups of 36 by random number table selection. The T-NMD group received oral NMD tablets combined with conventional rehabilitation training, and the NLC-NMD group received oral NMD and nanostructured lipid carrier (NLC-NMD) combined with exercise rehabilitation training. In both groups, the National Institute of Health stroke scores (NIHSS) were decreased, and the level of serum neurological function correlation index, upper and lower limb Fugl-Meyer assessment, modified Barthel index, and Montreal Cognitive Assessment scores were increased. The NLC-NMD group showed significantly lower NIHSS and significantly higher serum neurological function correlation index, upper and lower limb Fugl-Meyer assessment, modified Barthel index, and Montreal Cognitive Assessment scores (P < 0.05). The efficacy of the NLC-NMD group was significantly higher and complications significantly lower than the T-NMD group (P < 0.05). NLC, combined with exercise rehabilitation training, significantly affected stroke recovery and is worth popularizing and applying clinically.