Electrochemical sensors using screen-printed carbon electrode assemblies modified with the #beta#-cycldextrin or carboxymethylated #beta#-cyclodextrin polymer films for determination of tricyclic antidepressive drugs

摘要

Screen-printed carbon-based electrodes, operating as working electrodes of the single use commercial three-electrode assemblies, were surface modified with thin films of the condensation polymers of #beta#-cyclodextrin (#beta#-CDP) or carboxymethylated #beta#-cyclodextrin (#beta#-CDPA) in order to fabricate disposable electrochemical sensors for determination of tricyclic antidepressive drugs. The azepine and phenothiazine antidepressive drugs were determined by using a simple two-step procedure developed drugs. The azepine and phenothiazine antidepressive drugs were determined by using a simple two-step procedure developed which comprised a preconcentration step followed by the differential pulse voltammetry quantification. The accumulation properties of the #beta#-CDPA film appeared to be favorable as compared to those of the #beta#-CDP film. Concentration calibration curves were linear within the range from 1.96X10~(-7) to 2.75X10~(-6) M for individual drugs after 120s accumulation. The corresponding detection limits were from 4X10~(-8) to 5-10~(-7) M and 1X10~(-8) to 1.1X10~(-7)M for the #beta#-CDP and #beta#-CDPA-modified electrodes, respectively. A sensor featuring the #beta#-CDPA film-modified electrode was applied successfully for the antidepressant determination in a model serum.