A square-wave voltammetry (SWV) detection method for capillary electrophoresis (CE) using end-capillary detection is investigated. Although sensitive detection methods have been reported using off-capillary electrochemical detection methods, these methods typically use fragile carbon fiber electrodes and complex decoupling apparatus to separate the high separation voltage from the detection electronics. While end-column detection sys-terns are not usually as sensitive as off-column techniques, they require much simpler instrumentation and are more robust By modifying the 0steryoung SWV method to accommodate the high frequency sample rate required by CE, a detection limit of 5×10↑(-7) M (S/N = 10) was obtained for dopamine using end-capillary detection, which is comparable to sensitivities obtained using off-capillary detection with amperometric detection.
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机译：研究了使用毛细管末端检测的毛细管电泳（CE）的方波伏安法（SWV）检测方法。尽管已经报道了使用毛细管外电化学检测方法的灵敏检测方法，但是这些方法通常使用易碎的碳纤维电极和复杂的去耦设备将高分离电压与检测电子设备分开。虽然柱尾检测系统通常不像柱外技术那么灵敏，但它们需要更简单的仪器并且更强大。通过修改0steryoung SWV方法以适应CE要求的高频采样率，检测限为5使用毛细管末端检测获得多巴胺的×10↑（-7）M（S / N = 10），与使用毛细管外检测与安培检测获得的灵敏度相当。
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