MOFs-Derived Fe–N Codoped Carbon Nanoparticles as O2-Evolving Reactor and ROS Generator for CDT/PDT/PTT Synergistic Treatment of Tumors

摘要

Metal–organic frameworks (MOFs) derivatives had been widely explored in electronic and environmental fields, but rarely evaluated in the biomedical applications. Herein, Fe–N codoped carbon (FeNC) nanoparticles were synthesized and characterized via facile pyrolysis of precursor ZIF-8 (Fe/Zn) nanoparticles, and their potential applications in tumor therapy were assessed in this investigation both in vitro and in vivo. After PAA (sodium polyacrylate) modification, the [email?protected] nanoparticles were able to initiate a Fe-based Fenton-like reaction to generate ·OH and O_(2) for chemodynamic therapy (CDT) and O_(2) evolution. Meanwhile, the porphyrin-like metal center in the [email?protected] nanoparticles could be used as a photosensitizer for photodynamic therapy (PDT) of tumors, which could be enhanced by O_(2) generated in CDT. Furthermore, the [email?protected] nanoparticles were also found to be effective in photothermal therapy (PTT) with a photothermal conversion efficiency of 29.15%, owing to a high absorbance in the near-infrared region (NIR). In conclusion, the synthesized [email?protected] nanoparticles exhibited promising applications in O_(2) evolution and CDT/PDT/PTT synergistic treatment of tumors.