Highly Enantio- and Diastereoselective Organocatalytic Asymmetric Domino Michael-Aldol Reaction of β-Ketoesters and α,β-Unsaturated Ketones

摘要

The catalytic asymmetric formation of chiral building blocks represents an increasingly important field in organic chemistry owing to the usefulness of these products in further synthetic transformations. The catalytic enantioselective formation of CC bonds is a widely developed method for achieving this goal and a number of reactions and methodologies have been developed. Among the various asymmetric C-C bond-forming reactions, the direct catalytic domino and cycloaddition reactions are of particular interest as multiple stereogenic centers can be formed in a single reaction.