Organocatalytic Enantio- and Diastereoselective Acetalization of δ-Oxoenones via Cyanohydrin Formation

摘要

Due to the ubiquity in biologically active natural products and pharmaceuticals, chiral 1,3-diols have been gathered much attention as attractive synthetic targets. Although a number of stereoselective multistep syntheses of these structures have been reported to date, simultaneous catalytic construction of two stereogenic centers of chiral 1,3-diol structures is still challenging;; especially an approach to syn-1,3-diol motifs from achiral substrates with high level of stereocontrol remains unexploited.