Diastereoselective Reductive Amination of Aryl Trifluoromethyl Ketones and α-Amino Esters

摘要

The optimization of new drug entities depends on the manipulation of the potency, selectivity, adsorption, and metabolic properties of lead structures. One of the most commonly employed strategies for accomplishing these objectives involves the incorporation of fluorinated moieties into drug candidates, which often has a profound influence on their in vivo performance. As such, there has been intense interest in the stereoselective inclusion of fluorinated fragments into small organic molecules.