Internalization capabilities of gold-198 nanoparticles: Comparative evaluation of effects of chitosan agent on cellular uptake into MCF-7

摘要

In this study, internalization of positively charged chitosan-coated nanoparticles ((198)AuNPs@chitosan) on MCF-7 cells was investigated by gamma-ray spectroscopy and then statistically compared to that of Au-198 and negatively charged citrate-stabilized nanoparticles ((198)AuNPs). Sub-50 nm (198)AuNPs@chitosan had a higher internalization compared to Au-198 and (198)AuNPs 0.05). More cellular uptake of (AuNP)-Au-198@chitosan means a higher dose of radioactivity to the tumor cells which, in turn, more effective treatment of the cancer.