Preparation of polysaccharide-based chiral stationary phases on SiO 2@Ag core–shell particles by means of coating and intermolecular polycondensation and comparative liquid chromatography enantioseparations

摘要

AbstractMaterial with a core–shell structure based on a porous silica core and Ag nanoparticles (AgNPs) as shell (SiO2@Ag) was prepared with the seed growth method. Cellulose derivatives as chiral selectors were coated on the surfaces of SiO2@Ag particles by means of coating and intermolecular polycondensation as chiral stationary phases (CSPs), respectively. Fifteen racemates were used to evaluate their chiral recognition ability by high-performance liquid chromatography (HPLC). The results implied that the CSPs based on SiO2@Ag particles obtained stronger interaction with the analytes leading to better enantioseparation due to the existence of AgNPs on the surfaces of silica gel, compared with a cellulose derivative-modified silica column. In addition, the new CSPs showed special selectivity for ketone enantiomers, and AgNPs played a synergistic effect with cellulose derivatives on enantioseparation.

Graphical abstractSchematic of SiO2@Ag stationary phase

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