Letter to the editor: Decreased SIRT3 expression is a good potential biomarker associated with diseases

摘要

to the editor: Sirtuin-3 (SIRT3), one of the Sirtuin's family members, functions as a critical mitochondrial deacetylase, which implicates in a series of metabolic processes. However, the molecular mechanism of SIRT3 remains unclear. Recently, the article by Porter et al. (3), published in the American Journal of Physiology-Heart and Circulatory Physiology, manifested that SIRT3 knockdown cells were more vulnerable to simulated ischemia-reperfusion injury. The results hinted that decreased SIRT3 might increase the susceptibility of cardiac-derived cells and adult hearts to ischemia-reperfusion injury. It suggested that SIRT3 deficiency was a good potential biomarker associated with ischemia-reperfusion injury.