Involvement of Vascular Endothelial Growth Factor in Serotonin 1A Receptor-Mediated Neuroproliferation in Neonatal Mouse Hippocampus

摘要

Serotonin is one of the neurotransmitters that profoundly affect brain development. Serotonin influences neurogenesis, cell migration, dendritic refinement and synaptic plasticity. At a later developmental stage, it is shown to influence the length and branching of dendrites in the hippocampus and cortex (Sodhi and Sanders-Bush 2004). The serotonin 1A receptors (5-HT_(1A)-R) are found in both pre-synaptic and post-synaptic neurons of the hippocampus. While studies performed by other research teams have elucidated the signaling pathways linked to the presynaptic 5-HT_(1A)-R on the raphe-derived projections (Kushwaha and Albert 2005), our publications have systematically elucidated multiple 5-HT_(1A)-R-linked signaling pathways in the post-synaptic neurons located in the hippocampus and prefrontal cortex (Adayev et al. 1999, 2003, 2005; Mehta et al. 2007; Mogha et al. 2012; Purkayastha et al. 2012).