Effects of transition metal ion dopants (Ag, Cu and Fe) on the structural, mechanical and antibacterial properties of bioactive glass

摘要

Graphical abstractDisplay OmittedAbstractIn this investigation, an attempt has been made to provide comparative insight into the structural integrity, mechanical strength and anti-bacterial properties of three different transition metal ions namely Ag, Cu and Fe doped mesoporous nanobioglass for bone tissue engineering. Comparative29Si NMR of the various bioglass samples was elucidated for structural integrity evaluation. Interestingly, in spite of conventional Si network former substitution, herein Ag, Cu and Fe substituted the network modifier atomic sites at a concentration of 2wt%. This in turn affected the dissolution behavior of various ions present in the bioactive glass network. Henceforth, it potentiates the bioactive response as well as mechanical strength of the material. The mechanical response of the material against both sinusoidal and oscillatory stress forces has been measured. In terms of anti-bacterial properties, unlike the expected higher response of silver loaded bioglass, herein, interestingly copper followed by iron loaded bioactive glass displayed an excellent activity. It could be corroborated based on the structural parameters namely, network connectivity and dopant phase. The scarcity of literature data on the cytotoxicity of doped bioglass samples motivated us to evaluate the same. In brief, correlation between textural, structu