Combining High-Sensitivity Cardiac Troponin I and Cardiac Troponin T in the Early Diagnosis of Acute Myocardial Infarction

van der Linden Noreen; Wildi Karin; Twerenbold Raphael; Pickering John W.; Than Martin; Cullen Louise; Greenslade Jaimi; Parsonage William; Nestelberger Thomas; Boeddinghaus Jasper; Badertscher Patrick; Rubini Gimenez Maria; Klinkenberg Lieke J. J.; Bekers Otto; Schoni Aline; Keller Dagmar I.; Sabti Zaid; Puelacher Christian; Cupa Janosch; Schumacher Lukas; Kozhuharov Nikola; Grimm Karin; Shrestha Samyut; Flores Dayana; Freese Michael; Stelzig Claudia; Strebel Ivo; Miro Oscar; Rentsch Katharina; Morawiec Beata; Kawecki Damian; Kloos Wanda; Lohrmann Jens; Richards A. Mark; Troughton Richard; Pemberton Christopher; Osswald Stefan; van Dieijen-Visser Marja P.; Mingels Alma M.; Reichlin Tobias; Meex Steven J. R.; Mueller Christian

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Combining High-Sensitivity Cardiac Troponin I and Cardiac Troponin T in the Early Diagnosis of Acute Myocardial Infarction

机译：结合高灵敏度心肌肌钙蛋白I和心肌肌钙蛋白T在急性心肌梗死的早期诊断中

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摘要

Background: Combining 2 signals of cardiomyocyte injury, cardiac troponin I (cTnI) and T (cTnT), might overcome some individual pathophysiological and analytical limitations and thereby increase diagnostic accuracy for acute myocardial infarction with a single blood draw. We aimed to evaluate the diagnostic performance of combinations of high-sensitivity (hs) cTnI and hs-cTnT for the early diagnosis of acute myocardial infarction.

机译：背景：组合2个心肌细胞损伤的信号，心肌肌钙蛋白I（CTNI）和T（CTNT），可能会克服一些个体病理学和分析局限性，从而增加急性心肌梗死的诊断准确性，用单血绘制。我们旨在评估高敏感性（HS）CTNI和HS-CTNT组合的诊断性能，以便于急性心肌梗死的早期诊断。

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来源
《Circulation: An Official Journal of the American Heart Association》 |2018年第10期|共11页
作者
van der Linden Noreen; Wildi Karin; Twerenbold Raphael; Pickering John W.; Than Martin; Cullen Louise; Greenslade Jaimi; Parsonage William; Nestelberger Thomas; Boeddinghaus Jasper; Badertscher Patrick; Rubini Gimenez Maria; Klinkenberg Lieke J. J.; Bekers Otto; Schoni Aline; Keller Dagmar I.; Sabti Zaid; Puelacher Christian; Cupa Janosch; Schumacher Lukas; Kozhuharov Nikola; Grimm Karin; Shrestha Samyut; Flores Dayana; Freese Michael; Stelzig Claudia; Strebel Ivo; Miro Oscar; Rentsch Katharina; Morawiec Beata; Kawecki Damian; Kloos Wanda; Lohrmann Jens; Richards A. Mark; Troughton Richard; Pemberton Christopher; Osswald Stefan; van Dieijen-Visser Marja P.; Mingels Alma M.; Reichlin Tobias; Meex Steven J. R.; Mueller Christian;
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作者单位

MUMC Cardiovasc Res Inst Maastricht CARIM Dept Clin Chem Cent Diagnost Lab Maastricht;

Univ Hosp Basel Dept Cardiol Petersgraben 4 CH-4031 Basel Switzerland;

Univ Hosp Basel Dept Cardiol Petersgraben 4 CH-4031 Basel Switzerland;

Univ Otago Dept Med Christchurch New Zealand;

Univ Otago Dept Med Christchurch New Zealand;

Royal Brisbane &

Womens Hosp Dept Emergency Med Brisbane Qld Australia;

Queensland Univ Technol Sch Publ Hlth Brisbane Qld Australia;

Royal Brisbane &

Womens Hosp Dept Emergency Med Brisbane Qld Australia;

Univ Hosp Basel Dept Cardiol Petersgraben 4 CH-4031 Basel Switzerland;

Univ Hosp Basel Dept Cardiol Petersgraben 4 CH-4031 Basel Switzerland;

Univ Hosp Basel Dept Cardiol Petersgraben 4 CH-4031 Basel Switzerland;

Univ Hosp Basel Dept Cardiol Petersgraben 4 CH-4031 Basel Switzerland;

MUMC Cardiovasc Res Inst Maastricht CARIM Dept Clin Chem Cent Diagnost Lab Maastricht;

MUMC Cardiovasc Res Inst Maastricht CARIM Dept Clin Chem Cent Diagnost Lab Maastricht;

Univ Hosp Basel Dept Cardiol Petersgraben 4 CH-4031 Basel Switzerland;

Univ Hosp Zurich Emergency Dept Zurich Switzerland;

Univ Hosp Basel Dept Cardiol Petersgraben 4 CH-4031 Basel Switzerland;

Univ Hosp Basel Dept Cardiol Petersgraben 4 CH-4031 Basel Switzerland;

Univ Hosp Basel Dept Cardiol Petersgraben 4 CH-4031 Basel Switzerland;

Univ Hosp Basel Dept Cardiol Petersgraben 4 CH-4031 Basel Switzerland;

Univ Hosp Basel Dept Cardiol Petersgraben 4 CH-4031 Basel Switzerland;

Univ Hosp Basel Dept Cardiol Petersgraben 4 CH-4031 Basel Switzerland;

Univ Hosp Basel Dept Cardiol Petersgraben 4 CH-4031 Basel Switzerland;

Univ Hosp Basel Dept Cardiol Petersgraben 4 CH-4031 Basel Switzerland;

Univ Hosp Basel Dept Cardiol Petersgraben 4 CH-4031 Basel Switzerland;

Univ Hosp Basel Dept Cardiol Petersgraben 4 CH-4031 Basel Switzerland;

Univ Hosp Basel Dept Cardiol Petersgraben 4 CH-4031 Basel Switzerland;

Hosp Clin Barcelona Emergency Dept Barcelona Spain;

Univ Hosp Basel Lab Med Basel Switzerland;

Med Univ Katowice Dept Cardiol 2 Katowice Poland;

Med Univ Katowice Dept Cardiol 2 Katowice Poland;

Univ Hosp Basel Dept Cardiol Petersgraben 4 CH-4031 Basel Switzerland;

Univ Hosp Basel Dept Cardiol Petersgraben 4 CH-4031 Basel Switzerland;

Univ Otago Dept Med Christchurch New Zealand;

Univ Otago Dept Med Christchurch New Zealand;

Univ Otago Dept Med Christchurch New Zealand;

Univ Hosp Basel Dept Cardiol Petersgraben 4 CH-4031 Basel Switzerland;

MUMC Cardiovasc Res Inst Maastricht CARIM Dept Clin Chem Cent Diagnost Lab Maastricht;

MUMC Cardiovasc Res Inst Maastricht CARIM Dept Clin Chem Cent Diagnost Lab Maastricht;

Univ Hosp Basel Dept Cardiol Petersgraben 4 CH-4031 Basel Switzerland;

MUMC Cardiovasc Res Inst Maastricht CARIM Dept Clin Chem Cent Diagnost Lab Maastricht;

Univ Hosp Basel Dept Cardiol Petersgraben 4 CH-4031 Basel Switzerland;

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原文格式 PDF
正文语种 eng
中图分类心脏、血管（循环系）疾病;
关键词
combination; diagnosis; myocardial infarction; troponins;

机译：组合;诊断;心肌梗塞;肌钙蛋白;

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专利

1. Combining High-Sensitivity Cardiac Troponin I and Cardiac Troponin T in the Early Diagnosis of Acute Myocardial Infarction [J] . van der Linden Noreen, Wildi Karin, Twerenbold Raphael, Circulation: An Official Journal of the American Heart Association . 2018,第10期

机译：结合高灵敏度心肌肌钙蛋白I和心肌肌钙蛋白T在急性心肌梗死的早期诊断中
2. DIRECT COMPARISON OF HIGH-SENSITIVITY CARDIAC TROPONIN I VERSUS CONVENTIONAL TROPONIN I FOR THE EARLY DIAGNOSIS OF NON-ST ELEVATION MYOCARDIAL INFARCTION [J] . Saifullah Shabina, Ehsan Mian, Khalid Salma, Pakistan Heart Journal . 2019,第1期

机译：早期诊断非ST段抬高心肌梗死的高敏感性心肌肌钙蛋白I与常规肌钙蛋白I的直接比较
3. Release kinetics of high-sensitivity cardiac troponins I and T and troponin T upstream open reading frame peptide (TnTuORF) in clinically induced acute myocardial infarction [J] . Liebetrau Christoph, Gaede Luise, Wolter J. Sebastian, Biomarkers . 2017,第1a8期

机译：高敏性心肌肌钙蛋白I和T以及肌钙蛋白T上游开放阅读框肽（TnTuORF）在临床诱发的急性心肌梗死中的释放动力学
4. Cardiac troponin detection using silicon photonic biosensor for the accurate and timely diagnosis and prognosis of acute myocardial infarction [C] . Siew Joo Beh, Markus Knoerzer, Crispin Szydzik, Biophotonics Australasia Conference . 2019

机译：使用硅光子生物传感器的心肌肌钙蛋白检测，用于准确且及时的急性心肌梗死的诊断和预后
5. Association of high-sensitivity cardiac troponin,fibroblast growth factor 23 and left ventricular hypertrophy in Japanese patients with reduced renal function [D] . 伊藤, 敦巳 2019

机译：肾功能减退的日本人高敏感性心肌肌钙蛋白，成纤维细胞生长因子23与左心室肥厚的关系
6. High-sensitivity cardiac troponin I assays in the diagnosis of acute myocardial infarction [O] . Andrew R Chapman, David E Newby, Nicholas L Mills 2017

机译：高灵敏度心肌肌钙蛋白I测定对急性心肌梗死的诊断
7. MODERATED EPOSTERS1385Longitudinal strain assessment in dilated cardiomyopathy patients using a novel accelerated DENSE sequence1407Simultaneous T1 and T2 cardiac quantification with CABIRIA: initial clinical experience1423Head-to-head comparison of acceleration algorithms in 4-dimensional flow CMR1502Left ventricular function and size evaluated by hybrid cardiac positron emission tomography-magnetic resonance: Intraindividual comparison of left ventricular ejection fraction and ventricular volumes derived by two modalities1510Left Atrium assessed by Cardiovascular Magnetic Resonance at 1.5 and 3 Tesla – age and gender effects1514Comparison of Free Breathing Cardiac MRI Radial technique to the Standard Multi breath-hold cine SSFP CMR technique for the assessment of LV Volumes and Function1536Self-navigated free-breathing isotropic 3D whole heart phase sensitive inversion recovery magnetic resonance without navigator for detection of myocardial infarction1547Assessment of Right Ventricular Strain Using Myocardial Deformation Recovery Semi Automated Technique: Initial Experience and Normal Values1586Tissue tracking myocardial deformation analysis and prediction of left ventricular remodeling in acute myocardial infarction1589Investigating strategies for optimal 31P MRS clinical cardiac at 3T: Initial Results1620Quantitative Criteria for the Diagnosis of the Congenital Absence of Pericardium by Cardiac Magnetic Resonance1632Widespread tissue injury during acute myocardial infarction: evidence from advanced CMR relaxometry1322Computed tomography coronary angiography verSus sTRess cArdiac magneTic rEsonance for the manaGement of sYmptomatic revascularized patients: a cost effectiveness study (STRATEGY study)1339Comparison of low- versus high-dose of gadobutrol for late gadolinium enhancement imaging at 1.5 Tesla: a clinical feasibility study1347Multi-parametric Cardiac Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Intermedia: a Prospective Multicenter Study1461Prognostic value of Cardiovascular Magnetic Resonance derived indexes of myocardial fibrosis in heart transplant recipients1523The role of CMR in the acute phase of hospitalization: changing paradigms1542Preoperative CMR-based score predict ventricular response after surgical left ventricular reconstruction in ischemic heart failure patients1555Excellent response rate to cardiac resynchronization therapy guided with magnetic resonance imaging1626The ECG as a predictor of arrhythmogenic substrate on Cardiac Magnetic Resonance Imaging in patients undergoing ablation for premature ventricular contractions1649Comparison of T1-mapping at 3.0T CMR and angiographic APPROACH score for area at risk assessment in ST-segment elevation myocardial infarction1340Pathological correlates of left bundle branch disease in patients with non-ischemic cardiomyopathy: a cardiovascular magnetic resonance study1342Myocardial remodelling and fibrosis in nonischaemic dilated cardiomyopathy: insights from cardiovascular magnetic resonance1411The association between fibrosis and contractile dysfunction in hypertrophic cardiomyopathy assessed by cardiovascular magnetic resonance1622Persistent myocardial inflammation due to intramyocardial haemorrhage in reperfused STEMI as a precursor to adverse LV remodelling - insights from multi-parametric mapping1566Semiquantitative analysis of low and high b value DWI for detecting myocardial edema in acute myocarditis1567Value of Cardiac MRI In Detecting Coronary Artery Disease In Newly Diagnosed Systolic Dysfunction1570Usefulness of cardiac magnetic resonance in tuberous sclerosis complex1578Papillary muscles offer further insight into hypertrophied hearts: a cardiovascular magnetic resonance study1627Diagnostic and clinical implications of CMR timing (early versus late) in patients with troponin positive acute coronary syndromes and unobstructed coronary arteries: Table 1. [O] . Upasana Tayal, Alexandros Kallifatidis, P. Garg, 2016

机译：在使用新的扩张型心肌病的患者缓和EPOSTERS1385Longitudinal应变评估加速DENSE sequence1407Simultaneous T1和T2与CABIRIA心脏定量：在4维流动的加速算法初始临床experience1423Head对头比较CMR1502Left心室功能和尺寸由混合心脏正电子发射断层摄影术评价 - 磁性共振：由两个modalities1510Left庭派生左室射血分数和心室体积的个体间的比较，在1.5和3特斯拉评估心血管磁共振 - 免费的年龄和性别effects1514Comparison呼吸心脏MRI径向技术标准的多屏气电影SSFP CMR技术的LV卷和Function1536Self-导航自由呼吸各向同性3D整个心脏相位敏感反转恢复磁共振导航仪没有检测右Ventricu心肌infarction1547Assessment的评估拉尔菌株使用心肌变形恢复半自动技术：初步经验和正常Values1586Tissue跟踪心肌变形分析和预测左室重构急性心肌infarction1589Investigating策略优化31P MRS临床心脏在3T：初始Results1620Quantitative标准的先天缺失的诊断心包心脏磁Resonance1632Widespread组织损伤急性心肌梗死时：证据先进CMR relaxometry1322Computed CT冠状动脉成像与压力心脏磁共振对症的管理吻合血管患者：成本效益研究（战略研究）1339Comparison低与高剂量钆布醇在1.5特斯拉晚钆增强成像的临床可行性，在中间型地贫心脏并发症的预测study1347Multi参数心脏核磁共振的前瞻性德穆尔心血管磁共振的ticenter Study1461Prognostic价值衍生心肌纤维化指标在住院的急性期CMR的心脏移植recipients1523The作用：改变基于CMR-paradigms1542Preoperative比分预测缺血性心脏衰竭patients1555Excellent响应速度外科左心室重建心脏再同步化后心室反应治疗与磁共振imaging1626The ECG导引作为心脏磁共振成像致心律失常性基板的在ST段抬高心肌infarction1340Pathological在风险评估经历在3.0T CMR T1映射的室性早搏contractions1649Comparison和血管造影APPROACH分数区域消融患者的预测左束支传导疾病的患者与非缺血性心肌病相关因素：心血管磁共振study1342Myocardial重塑和纤维化nonischaemic扩张型心肌病：在从在由心血管磁性resonance1622Persistent心肌炎症评估肥厚型心肌病的纤维化和收缩功能障碍之间心血管磁性resonance1411The协会由于心肌内出血景点在再灌注STEMI为先导，以不利的LV重塑 - 从低的多参数mapping1566Semiquantitative分析和高的b值DWI的见解为在心脏MRI检测冠状动脉疾病急性myocarditis1567Value在结节性硬化症complex1578Papillary肌肉初诊收缩期Dysfunction1570Usefulness心脏磁共振检测心肌水肿提供进一步的深入了解肥大心脏：心血管磁共振study1627Diagnostic和CMR定时的临床意义（早期与晚）患者肌钙蛋白阳性的急性冠脉综合征和通畅的冠状动脉：表1。

Combining High-Sensitivity Cardiac Troponin I and Cardiac Troponin T in the Early Diagnosis of Acute Myocardial Infarction

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