Walk a mile in my shoes.

摘要

A significant fraction of the articles in Anesthesia & Analgesia report the results of clinical trials funded by government agencies (e.g., National Institutes of Health), the pharmaceutical industry, or by the institution in which the investigators work. The design of clinical trials is a challenging process in which investigators balance their desire to answer many questions with high levels of certainty against the realities of funding, ethical considerations, magnitude of effort, and other practicalities. As pointed out previously, the perfect trial cannot be performed. All trials are imperfect, and some are even highly flawed, in that the trial design cannot answer any question in a meaningful way.