PD-L1 expression in non-small cell lung carcinoma: Comparison among cytology, small biopsy, and surgical resection specimens

Heymann Jonas J.; Bulman William A.; Swinarski David; Pagan Carlos A.; Crapanzano John P.; Haghighi Mehrvash; Fazlollahi Ladan; Stoopler Mark B.; Sonett Joshua R.; Sacher Adrian G.; Shu Catherine A.; Rizvi Naiyer A.; Saqi Anjali

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PD-L1 expression in non-small cell lung carcinoma: Comparison among cytology, small biopsy, and surgical resection specimens

机译：非小细胞肺癌中的PD-L1表达：细胞学，小型活组织检查和手术切除标本的比较

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BACKGROUNDOne immunotherapeutic agent for patients with advanced non-small cell lung carcinoma, pembrolizumab, has a companion immunohistochemistry (IHC)-based assay that predicts response by quantifying programmed death-ligand 1 (PD-L1) expression. The current study assessed the feasibility of quantifying PD-L1 expression using cytologic non-small cell lung carcinoma specimens and compared the results with those from small biopsy and surgical resection specimens.

机译：背景技术免疫治疗剂，用于高级非小细胞肺癌，Pembrolizumab，具有伴随的免疫组织化学（IHC），基于伴随量的测定，其通过定量编程的死亡配体1（PD-L1）表达来预测响应。目前的研究评估了使用细胞学非小细胞肺癌样本定量PD-L1表达的可行性，并将结果与来自小活组织检查和手术切除术样品的结果进行比较。

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来源
《Cancer: A Journal of the American Cancer Society 》 |2017年第12期| 共12页
作者
Heymann Jonas J.; Bulman William A.; Swinarski David; Pagan Carlos A.; Crapanzano John P.; Haghighi Mehrvash; Fazlollahi Ladan; Stoopler Mark B.; Sonett Joshua R.; Sacher Adrian G.; Shu Catherine A.; Rizvi Naiyer A.; Saqi Anjali;
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作者单位

Columbia Univ Dept Pathol &

Cell Biol New York Presbyterian Hosp Irving Med Ctr New York NY USA;

Columbia Univ Dept Med New York Presbyterian Hosp Irving Med Ctr New York NY USA;

Fordham Univ Dept Math New York NY 10023 USA;

Columbia Univ Dept Pathol &

Cell Biol New York Presbyterian Hosp Irving Med Ctr New York NY USA;

Columbia Univ Dept Pathol &

Cell Biol New York Presbyterian Hosp Irving Med Ctr New York NY USA;

Columbia Univ Dept Pathol &

Cell Biol New York Presbyterian Hosp Irving Med Ctr New York NY USA;

Columbia Univ Dept Pathol &

Cell Biol New York Presbyterian Hosp Irving Med Ctr New York NY USA;

Columbia Univ Dept Med New York Presbyterian Hosp Irving Med Ctr New York NY USA;

Columbia Univ Dept Surg New York Presbyterian Hosp Irving Med Ctr New York NY USA;

Columbia Univ Dept Med New York Presbyterian Hosp Irving Med Ctr New York NY USA;

Columbia Univ Dept Med New York Presbyterian Hosp Irving Med Ctr New York NY USA;

Columbia Univ Dept Med New York Presbyterian Hosp Irving Med Ctr New York NY USA;

Columbia Univ Dept Pathol &

Cell Biol New York Presbyterian Hosp Irving Med Ctr New York NY USA;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学 ;
关键词
endoscopic ultrasound-guided fine-needle aspiration (EBUS-FNA); immunotherapy; programmed cell death protein 1 (PD-1); programmed death-ligand 1 (PD-L1); non-small cell lung cancer (NSCLC); reproducibility; small biopsy;

机译：内窥镜超声引导的细针吸气（EBUS-FNA）;免疫疗法;编程的细胞死亡蛋白1（PD-1）;编程死亡 - 配体1（PD-L1）;非小细胞肺癌（NSCLC）;再现性;小活组织检查;

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专利

1. PD-L1 expression in non-small cell lung carcinoma: Comparison among cytology, small biopsy, and surgical resection specimens [J] . Heymann Jonas J., Bulman William A., Swinarski David, Cancer: A Journal of the American Cancer Society . 2017 ,第12期

机译：非小细胞肺癌中的PD-L1表达：细胞学，小型活组织检查和手术切除标本的比较
2. Accuracy of Cytology Specimen and Needle Core Biopsies for Detection of KRAS Mutation in Non-Small Cell Carcinoma: Comparison With Resection Specimen [J] . Ismatun Swati, Shengle Zhang, Jamie Tull, World Journal of Oncology . 2011 ,第6期

机译：细胞学标本和针芯活检在非小细胞癌中检测KRAS突变的准确性：与切除标本的比较
3. Concordance of PD-L1 Expression Between Core Biopsy and Resection Specimens of Non-Small Cell Lung Cancer [J] . Gradecki Sarah E., Grange Jacob S., Stelow Edward B. American Journal of Surgical Pathology . 2018 ,第8期

机译：非小细胞肺癌核心活检和切除分析的PD-L1表达的一致性
4. Supporting the stratification of non-small cell lung carcinoma for Anti PD-L1 immunotherapy with digital image registration [C] . Francisco Cunha, Catarina Eloy, Nuno Matela IEEE Portuguese Meeting in Bioengineering . 2019

机译：通过数字图像配准支持非小细胞肺癌分层用于抗PD-L1免疫治疗
5. Regulation and Consequences of PD-L1 Expression in Non-Small Cell Lung Cancer [D] . Lastwika, Kristin J. 2014

机译：PD-L1表达在非小细胞肺癌中的调节及后果
6. Accuracy of Cytology Specimen and Needle Core Biopsies for Detection of KRAS Mutation in Non-Small Cell Carcinoma: Comparison With Resection Specimen [O] . Ismatun Swati, Shengle Zhang, Jamie Tull, 2011

机译：细胞学标本和针芯活检在非小细胞癌中检测KRAS突变的准确性：与切除标本的比较
7. Subtyping of Non-small Cell Lung Carcinoma: A Comparison of Small Biopsy and Cytology Specimens [O] . Sigel Carlie S., Moreira Andre L., Travis William D., 2011

机译：非小细胞肺癌亚型：小活检和细胞学标本的比较

PD-L1 expression in non-small cell lung carcinoma: Comparison among cytology, small biopsy, and surgical resection specimens

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