Microbiome influences von Willebrand factor

摘要

In this issue of Blood, Jackel et al define an unexpected role for the microbiome in regulating murine plasma von Willebrand factor (VWF) levels. In particular, commensal gut microbiota are shown to regulate VWF synthesis in liver sinusoidal endothelial cells through a Toll-like receptor-2 (TLR2)-dependent pathway. Collectively, these novel findings provide important insights into the biological mechanisms through which commensal microbiota may modulate cardiovascular pathology.