Neutrophils: positive or negative?

摘要

In this issue of Blood, Valgardsdottir et al demonstrate that human neutrophils do not kill chronic lymphocytic leukemia (CLL) B cells opsonized with the CD20 monoclonal antibody (mAb) rituximab (RTX) or obinutuzumab (OBZ); instead, the neutrophils remove both CD20 and bound mAbs from B cells by trogocytosis.(1)