JMML patient-derived iPSCs induce new hypotheses.

摘要

How many platelets are needed for hemostasis? Are low platelet counts protective from thrombosis? Why do immune thrombocytopenia-(ITP) patients have myocardial infarctions (Mis) and strokes? Why do some patients bleed and others do not at comparably low platelet counts? As anyone who has formulated guidelines or is in clinical practice knows, there is considerable empiricism but little actual data available to answer these questions.The answer: relatively few platelets are necessary for thrombosis. The authors asked the seemingly simple question of how low can the platelet count fall in a mouse before interfering with common models of thrombosis. Thrombosis of small, medium, and large vessels remained intact at platelet counts down to 10% to 30% of normal. Mice ultimately need <2.5% of their normal platelet number to maintain the most basic level of hemostasis.