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首页> 外文期刊>BioMed research international >The Preventive Effect of Oxytocin to Cisplatin-Induced Neurotoxicity: An Experimental Rat Model
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The Preventive Effect of Oxytocin to Cisplatin-Induced Neurotoxicity: An Experimental Rat Model

机译:催产素对顺铂诱导神经毒性的预防作用:实验大鼠模型

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摘要

Peripheral neurotoxicity is a frequent dose-limiting side effect of the chemotherapeutic agent cisplatin. This study was conducted to investigate the preventive effect of oxytocin (OT) on cisplatin-induced neurotoxicity in rats. Forty-four adult female rats were included in the study. Thirty-six rats were administered intraperitoneally (i.p.) single dose cisplatin 10 mg/kg and divided in to 3 groups. The first group (n = 12) received saline i.p., whereas the second group (n = 12) and the third group (n = 12) were injected with 80μg/kg and 160μg/kg OT, respectively, for 10 days. The remaining 8 rats served as the control group. Electromyography (EMG) studies were recorded and blood samples were collected for the measurement of plasma lipid peroxidation (malondialdehyde; MDA), tumor necrosis factor (TNF)-α, and glutathione (GSH) levels. EMG findings revealed that compound muscle action potential amplitude was significantly decreased and distal latency was prolonged in the nontreated cisplatin-injected rats compared with the control group (P < 0.005). Also, nontreated cisplatin-injected rats showed significantly higher TNF-α and MDA levels and lower GSH level than control group. The administration of OT significantly ameliorated the EMG alterations, suppressed oxidative stress and inflammatory parameters, and increased antioxidative capacity. We suggest that oxytocin may have beneficial effects against cisplatin-induced neurotoxicity.
机译:外周神经毒性是化学治疗剂顺铂的常见剂量限制副作用。进行该研究以研究催产素(OT)对大鼠顺铂诱导的神经毒性的预防作用。研究中包括四十四只成年女性大鼠。腹膜内(I.P.)单剂量顺铂10mg / kg施用36只大鼠,并分为3组。第一组(n = 12)接受盐水I.p.,而第二组(n = 12)和第三组(n = 12)分别用80μg/ kg和160μg/ kg ot注入10天。其余8只大鼠用作对照组。记录肌电图(EMG)研究,并收集血液样品以测量血浆脂质过氧化(丙二醛; MDA),肿瘤坏死因子(TNF)-α和谷胱甘肽(GSH)水平。 EMG发现显示,与对照组相比,在非生成的顺铂喷射大鼠中,复合肌动作势幅度显着降低,远端等待时间延长了(P <0.005)。此外,非生成的顺铂注入的大鼠显示出明显高的TNF-α和MDA水平和低于对照组的GSH水平。 OT的给药显着改善了EMG改变,抑制氧化应激和炎症参数,以及增加的抗氧化能力。我们表明催产素可能对顺铂诱导的神经毒性有益效果。

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