Vaccination with a DNA vaccine encoding CD317-targeting HBs antigen elicits enhanced immunity in mice

Zhang Guizhong; Li Xin; Liu Lvyan; Li Junxin; Chen Qian; Huang Shiran; Li Yutao; Wan Xiaochun

首页> 外文期刊>Biochemical and Biophysical Research Communications >Vaccination with a DNA vaccine encoding CD317-targeting HBs antigen elicits enhanced immunity in mice

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Vaccination with a DNA vaccine encoding CD317-targeting HBs antigen elicits enhanced immunity in mice

机译：用编码CD317靶向HBS抗原的DNA疫苗接种疫苗接种疫苗引发小鼠的免疫力增强

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Background: Conventional hepatitis B virus (HBV) vaccines fail to induce protective antibody titers in 5 -10% of immune-competent vaccines. Therefore, safe and effective HBV vaccines are still clinically needed.

机译：背景：常规乙型肝炎病毒（HBV）疫苗未诱导5-10％的免疫态疫苗中的保护抗体滴度。因此，仍然需要安全和有效的HBV疫苗。

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来源
《Biochemical and Biophysical Research Communications》 |2018年第4期|共6页
作者
Zhang Guizhong; Li Xin; Liu Lvyan; Li Junxin; Chen Qian; Huang Shiran; Li Yutao; Wan Xiaochun;
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作者单位

Chinese Acad Sci Inst Biomed &

Biotechnol Shenzhen Inst Adv Technol Shenzhen Lab Fully Human;

Chinese Acad Sci Inst Biomed &

Biotechnol Shenzhen Inst Adv Technol Shenzhen Lab Fully Human;

Chinese Acad Sci Inst Biomed &

Biotechnol Shenzhen Inst Adv Technol Shenzhen Lab Fully Human;

Chinese Acad Sci Inst Biomed &

Biotechnol Shenzhen Inst Adv Technol Shenzhen Lab Fully Human;

Chinese Acad Sci Inst Biomed &

Biotechnol Shenzhen Inst Adv Technol Shenzhen Lab Fully Human;

Chinese Acad Sci Inst Biomed &

Biotechnol Shenzhen Inst Adv Technol Shenzhen Lab Fully Human;

Shenzhen BinDeBioTech Co Ltd Floor 5 Bldg 6 Shenzhen 518055 Peoples R China;

Chinese Acad Sci Inst Biomed &

Biotechnol Shenzhen Inst Adv Technol Shenzhen Lab Fully Human;

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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
DNA vaccine; CD317-Targeting; HBsAg; HBV infection;

机译：DNA疫苗;CD317靶向;HBsAg;HBV感染;

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专利

1. Vaccination with a DNA vaccine encoding CD317-targeting HBs antigen elicits enhanced immunity in mice [J] . Zhang Guizhong, Li Xin, Liu Lvyan, Biochemical and Biophysical Research Communications . 2018,第4期

机译：用编码CD317靶向HBS抗原的DNA疫苗接种疫苗接种疫苗引发小鼠的免疫力增强
2. Modulation of immune response induced by co-administration of DNA vaccine encoding HBV surface antigen and HCV envelope antigen in BALB/c mice. [J] . Nam SH, Park JH, Kang JH, Archives of pharmacal research . 2006,第11期

机译：在BALB / c小鼠中共同施用编码HBV表面抗原和HCV包膜抗原的DNA疫苗诱导的免疫应答调节。
3. DNA Fragment Encoding Human IL-1β 163–171 Peptide Enhances the Immune Responses Elicited in Mice by DNA Vaccine against Foot-and-Mouth Disease [J] . H.-J. Shao, L. Chen, Y.-B. Su Veterinary Research Communications . 2005,第1期

机译：编码人IL-1β163-171肽的DNA片段增强了针对口蹄疫的DNA疫苗诱发的小鼠免疫应答
4. POLY(D,L-LACTIC ACID) ENHANCES IMMUNE RESPONSES TO LIPOSOMAL DNA ENCODED ANTIGEN: MULTICOMPONENT PLASMID DNA DELIVERY SYSTEMS [C] . V. Bramwell, J. Eyles, S. Somavarapu, International symposium on controlled release of bioactive materials;Consumer diversified products conference . 2001

机译：聚（D，L-乳酸）增强了对脂质体DNA编码抗原的免疫反应：多组分质粒DNA递送系统
5. Characterization of the type immune responses using different forms of antigen and different methods of DNA vaccination. [D] . Oran, Alp Eren. 2003

机译：使用不同形式的抗原和不同的DNA疫苗接种方法表征类型的免疫反应。
6. A Fusion DNA Vaccine Encoding Middle Version of HBV Envelope Protein Fused to Interleukin-21 Did Not Enhance HBV-Specific Immune Response in Mice [O] . Ye Zhang, Wen-Jing Su, Jue Wang, -1

机译：融合至白细胞介素21的中间版本的HBV信封蛋白的融合DNA疫苗不能增强小鼠的HBV特异性免疫反应。
7. A Fusion DNA Vaccine Encoding Middle Version of HBV Envelope Protein Fused to Interleukin-21 Did Not Enhance HBV-Specific Immune Response in Mice [O] . Ye Zhang, Wen-Jing Su, Jue Wang, 2014

机译：编码与白细胞介素-21融合的HBV包膜蛋白的中间版本的融合DNA疫苗没有提高小鼠的HBV特异性免疫应答
8. Multi-Agent Alphavirus DNA Vaccine Delivered by Intramuscular Electroporation Elicits Robust and Durable Virus Specific Immune Responses in Mice and Rabbits and Completely Protects Mice against Lethal Venezuelan, Western, and Eastern Equine Encephalitis Virus Aerosol Challenges. [R] . Dupuy, L. C., Richards, M. J., Livingston, B. D., 2016

机译：通过肌内电穿孔提供的多剂甲病毒DNa疫苗在小鼠和家兔中引发健壮和耐久的病毒特异性免疫应答，并完全保护小鼠免受致命的委内瑞拉，西方和东方马脑炎病毒气溶胶挑战。

Vaccination with a DNA vaccine encoding CD317-targeting HBs antigen elicits enhanced immunity in mice

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