Introduction of a conserved sequence into the 5 ' UTR of additional transcription down-regulation expression of foreign proteins of measles virus minigenome

摘要

The noncoding sequences in the UTR between the Gene Start signal (GS) and the initial codon AUG from 25 measles virus genomes were compared. The conserved sequences 5'-U(NNNNN)(5-8) -3' and 5'(CNNNNNC)-3' were found in the genome and the UTR of phosphoprotein (P) and Fusion (F) mRNA. These sequences were named the U-Unit and the C-Unit, respectively. These two sequences are different in the P and F mRNAs.