purified polypeptide, purified polyclonal or monoclonal antibody, expression vector, purified polynucleotide sequence, use of a polynucleotide sequence, recombinant viral vector, recombinant measles virus, pharmaceutical composition, use thereof, host cell, method for producing a recombinant virus for the production of a recombinant virus, cell line, West Nile virus neutralization assay, and method for treating and / or preventing an infection or disease associated with wnv or dengue virus in an animal

摘要

"Polypeptide PURIFIED, antibody polyclonal or monoclonal PURIFIED, EXPRESSION VECTOR, polynucleotide PURIFIED sequence, A polynucleotide sequence USE, VIRAL VECTOR RECOMBINANT, measles RECOMBINANT, PHARMACEUTICAL COMPOSITION, THE SAME USE, host cell, METHOD FOR PRODUCING A virus RECOMBINANT FOR THE PRODUCTION OF A RECOMBINANT VIRUS, CELL LINING WEST NILE VIRUS NEUTRALIZATION TEST, AND METHOD FOR TREATING AND / OR PREVENTING AN INFECTION OR DISEASE ASSOCIATED WITH A WNV OR VIN D "VIRUS. The present invention relates to the development of viral vectors expressing different West Nile Encephalitis Virus (WNV) or Dengue virus immunogens that are capable of inducing protective cellular and humoral responses against WNV virus infections or from Dengue. More specifically, the present invention relates to three (3) WNV antigens (secreted envelope glycoprotein (E), heterodimer glycoproteins (pre-ME) and NSI protein) and dengue virus (glycoprotein ( e) from the secreted envelope, heterodimer glycoproteins (pre-me) and protein ns1) and their use in vaccine, therapeutic and diagnostic applications.