Each liver X receptor (LXR) type has a different purpose in different situations

Yonezawa Sei; Abe Mizuho; Kawasaki Yasushi; Natori Yasuhiro; Sugiyama Akinori

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Each liver X receptor (LXR) type has a different purpose in different situations

机译：每个肝X受体（LXR）类型在不同情况下具有不同的目的

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摘要

LXRs, which are nuclear receptors, have 2 isoforms-LXR alpha and LXR beta. Generally, LXR alpha, is expressed in the liver, kidney, and a limited number of other organs, whereas LXR beta is thought to be expressed ubiquitously. Nevertheless, no clear consensus has been reached on the role of each in kidney lipid metabolism.

机译：LXRS是核受体，具有2个同种型-LXRα和LXRβ。通常，LXRα在肝脏，肾脏和有限数量的其他器官中表达，而LXRβ被认为是普遍的。然而，没有明确的共识，以肾脂质代谢的作用。

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来源
《Biochemical and Biophysical Research Communications》 |2019年第1期|共5页
作者
Yonezawa Sei; Abe Mizuho; Kawasaki Yasushi; Natori Yasuhiro; Sugiyama Akinori;
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作者单位

Iwate Med Univ Sch Pharm Hlth Chem 2-1-1 Nishitokuta Yahaba Iwate 0283694 Japan;

Iwate Med Univ Sch Pharm Hlth Chem 2-1-1 Nishitokuta Yahaba Iwate 0283694 Japan;

Iwate Med Univ Sch Pharm Hlth Chem 2-1-1 Nishitokuta Yahaba Iwate 0283694 Japan;

Iwate Med Univ Sch Pharm Hlth Chem 2-1-1 Nishitokuta Yahaba Iwate 0283694 Japan;

Iwate Med Univ Sch Pharm Hlth Chem 2-1-1 Nishitokuta Yahaba Iwate 0283694 Japan;

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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
Nuclear receptor; LXR; Lipid metabolism; Kidney; Nephrosis;

机译：核受体;LXR;脂质代谢;肾脏;肾病;

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专利

1. Each liver X receptor (LXR) type has a different purpose in different situations [J] . Yonezawa Sei, Abe Mizuho, Kawasaki Yasushi, Biochemical and Biophysical Research Communications . 2019,第1期

机译：每个肝X受体（LXR）类型在不同情况下具有不同的目的
2. Carbohydrate-response-element-binding protein (ChREBP) and not the liver X receptor α (LXRα) mediates elevated hepatic lipogenic gene expression in a mouse model of glycogen storage disease type?1 [J] . Albert?K. Groen, Aldo Grefhorst, Andreas?W. Herling, The biochemical journal . 2010,第2期

机译：在糖原贮积病类型为1的小鼠模型中，糖反应因子结合蛋白（ChREBP）而非肝X受体α（LXRα）介导了肝脂肪生成基因表达的升高。
3. Carbohydrate-response-element-binding protein (ChREBP) and not the liver X receptor (LXR) mediates elevated hepatic lipogenic gene expression in a mouse model of glycogen storage disease type 1. [J] . Grefhorst A, Schreurs M, Oosterveer MH, The Biochemical Journal . 2010,第2期

机译：在糖原贮积病1型小鼠模型中，碳水化合物-反应因子-结合蛋白（ChREBP）而不是肝X受体（LXR）介导肝脂肪生成基因表达的升高。
4. Change of ATP binding cassette transporter A1 and liver X receptor α expression in diabetic minipig skeletal muscle Change of LXRα/ABCA1 pathway in diabetic skeletal muscle [C] . Shi-Lin Tang, Yin Kai, Zhong-Cheng Mo, 2011 International Conference on Remote Sensing, Environment and Transportation Engineering . 2011

机译：糖尿病迷你猪骨骼肌中ATP结合盒转运蛋白A1和肝X受体α表达的变化糖尿病骨骼肌LXRα/ ABCA1途径的变化
5. Structure-function studies of adenovirus type 5 fiber protein and its receptor CAR: Implications for adenovirus cell entry mechanism and gene delivery. [D] . Chen, Xinhua. 2003

机译：5型腺病毒纤维蛋白及其受体CAR的结构功能研究：对腺病毒细胞进入机制和基因传递的影响。
6. Liver X Receptor-Retinoid X Receptor (LXR-RXR) Heterodimer Cistrome Reveals Coordination of LXR and AP1 Signaling in Keratinocytes [O] . Qi Shen, Yuchen Bai, Ken C. N. Chang, 2011

机译：肝X受体-类维生素A X受体（LXR-RXR）异二聚体综合征揭示了角质形成细胞中LXR和AP1信号的协调。
7. Carbohydrate-response-element-binding protein (ChREBP) and not the liver X receptor α (LXRα) mediates elevated hepatic lipogenic gene expression in a mouse model of glycogen storage disease type 1 [O] . Grefhorst, Aldo, Schreurs, Marijke, Oosterveer, Maaike H, 2010

机译：在糖原贮积病1型小鼠模型中，碳水化合物-反应因子-结合蛋白（ChREBP）而非肝X受体α（LXRα）介导肝脂肪生成基因表达的升高

Each liver X receptor (LXR) type has a different purpose in different situations

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