USE OF BRASSINOSTEROID ANALOGS FOR THE TREATMENT OF DERMAL DISORDERS BY SELECTIVELY MODULATING LIVER X RECEPTORS (LXR) AND DERMAL DISEASE TREATMENT BY BRASSINOSTEROID ANALOGS ACTING AS SELECTIVE LIVER X RECEPTOR (LXR) MODULATORS

摘要

The present invention relates to the use of brassinosteroid analogs for the treatment of dermal disorders or conditions. One embodiment is the topical application of at least one brassinosteroid analog described herein for the treatment of psoriasis in a mammal. The present invention describes the use of brassinosteroid analogs of general formula (a). (a) (I) wherein, R₁, R₂, and R3 are selected from H, H0-, linear or branched C1-C4 alkyl, R₅-O-, HCOO-, R₅-COO-, -OOC-R₆-COO-, p-toluene sulphonate, phosphate, tartrate, maleate, sulphate, fluorine, chlorine, bromine, iodine and methanesulphonate, R₄ and R₅ are selected from H and linear or branched C1-C4 alkyl, R₆ is -(CH2)n- wherein n equals to 1, 2 or 3, and can be a single or double bond An embodiment of the present invention describes a method of therapeutic treatment for psoriasis, skin aging, rosacea, dermatitis, burns, skin cancer and malignancies, and pigmentary derangements, by means of administration of brassinosteroid analogs of general formula (a).