A fluorescent probe for GM1 gangliosidosis related β-galactosidase: N-(Dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-d-galactitol

Fr?hlichR.F.G.; FanturK.; FurneauxR.H.; PaschkeE.; StützA.E.; WickiJ.; WithersS.G.; WrodniggT.M.

首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >A fluorescent probe for GM1 gangliosidosis related β-galactosidase: N-(Dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-d-galactitol

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A fluorescent probe for GM1 gangliosidosis related β-galactosidase: N-(Dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-d-galactitol

机译：用于GM1神经糖苷中的荧光探针相关β-半乳糖苷酶：N-（丹氨酰氨基）己基氨基羰基戊基-1,5-二赤氧基-1,5-亚氨基-d-半乳糖醇

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摘要

N-(Dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-d-galactitol, a strong competitive inhibitor of β-galactosidase, enhances residual β-galactosidase activities in fibroblasts and serves as lead en route to diagnostic compounds for tracking the fate of mutant β-gal as well as aberrant GM1 gangliosides by live cell imaging.

机译：N-（丹氨酰氨基）己氨基氨基羰基戊基-1,5-二赤氧基-1,5-亚氨基-d-酰亚胺-Galactolol，β-半乳糖苷酶的强竞争性抑制剂，增强了成纤维细胞中的残留β-半乳糖苷酶活性，并用作诊断化合物的途径通过活细胞成像跟踪突变体β-GAL的命运以及Aperrant Gm1神经节苷脂。

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来源
《Bioorganic and Medicinal Chemistry Letters》 |2011年第22期|共4页
作者
Fr?hlichR.F.G.; FanturK.; FurneauxR.H.; PaschkeE.; StützA.E.; WickiJ.; WithersS.G.; WrodniggT.M.;
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作者单位

Carbohydrate Chemistry Team Industrial Research Limited PO Box 31-310 5040 Lower Hutt New;

Department of Pediatrics Medical University Graz Auenbruggerplatz 30 A-8010 Graz Austria;

Carbohydrate Chemistry Team Industrial Research Limited PO Box 31-310 5040 Lower Hutt New;

Department of Pediatrics Medical University Graz Auenbruggerplatz 30 A-8010 Graz Austria;

Glycogroup Institut für Organische Chemie Technische Universit?t Graz Stremayrgasse 9 A-8010;

Chemistry Department University of British Columbia 2036 Main Mall Vancouver BC V6T 1Z1 Canada;

Chemistry Department University of British Columbia 2036 Main Mall Vancouver BC V6T 1Z1 Canada;

Glycogroup Institut für Organische Chemie Technische Universit?t Graz Stremayrgasse 9 A-8010;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
d-Galactosidase inhibitor; Fluorescent probe; GM1 gangliosidosis; Iminoalditols; Pharmacological chaperone;

机译：D-半乳糖苷酶抑制剂;荧光探针;GM1神经节病毒;IMINOALDINOLS;药理伴侣;

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专利

1. A fluorescent probe for GM1 gangliosidosis related β-galactosidase: N-(Dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-d-galactitol [J] . Fr?hlichR.F.G., FanturK., FurneauxR.H., Bioorganic and Medicinal Chemistry Letters . 2011,第22期

机译：用于GM1神经糖苷中的荧光探针相关β-半乳糖苷酶：N-（丹氨酰氨基）己基氨基羰基戊基-1,5-二赤氧基-1,5-亚氨基-d-半乳糖醇
2. Intracerebroventricular enzyme replacement therapy with β-galactosidase reverses brain pathologies due to GM1 gangliosidosis in mice [J] . Joseph C. Chen, Amanda R. Luu, Nathan Wise, The Journal of biological chemistry . 2020,第39期

机译：β-半乳糖苷酶的脑内酶酶替代治疗因小鼠GM1神经节病而导致脑病理逆转
3. Uptake, lysosomal activation, and disease correction in GM1 Gangliosidosis cells by plant-made beta-galactosidase: Lectin fusions [J] . Ayala Jorge, Acosta Walter, Condori Jose, Molecular genetics and metabolism . 2016,第2期

机译：植物性β-半乳糖苷酶：凝集素融合蛋白在GM1神经节苷脂病细胞中的摄取，溶酶体激活和疾病纠正
4. 1-Deoxy-d-galactonojirimycins with dansyl capped N-substituents as β-galactosidase inhibitors and potential probes for GM1 gangliosidosis affected cell lines [O] . Richard F.G. Fröhlich, Richard H. Furneaux, Don J. Mahuran, -1

机译：1-脱氧-d-半乳糖苷嘧啶类药物带有丹磺酰基封端的N-取代基作为β-半乳糖苷酶抑制剂和GM1神经节病影响细胞系的潜在探针
5. 1-Deoxy-d-galactonojirimycins with dansyl capped N-substituents as β-galactosidase inhibitors and potential probes for GM1 gangliosidosis affected cell lines [O] . Fröhlich, Richard F.G., Furneaux, Richard H., Mahuran, Don J., 2011

机译：1-脱氧-d-半乳糖苷嘧啶类药物，带有丹磺酰基封端的N-取代基作为β-半乳糖苷酶抑制剂和GM1神经节病影响细胞系的潜在探针
6. N-(3-Pyrene)succinimidothioethanol. A Fluorescent Probe Sensitive to pH and Redox Potential. [R] . Liburdy, R. P. 1977

机译：N-（3-芘）succinimidothioethanol。荧光探针对pH和氧化还原电位敏感。

A fluorescent probe for GM1 gangliosidosis related β-galactosidase: N-(Dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-d-galactitol

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