Synthesis and in vitro antitubercular activity of 4-aryl/ alkylsulfonylmethylcoumarins as inhibitors of Mycobacterium tuberculosis

JeyachandranM.; RameshP.; SriramD.; SenthilkumarP.; YogeeswariP.

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Synthesis and in vitro antitubercular activity of 4-aryl/ alkylsulfonylmethylcoumarins as inhibitors of Mycobacterium tuberculosis

机译：4-芳基/烷基磺酰基甲基丙氨酸作为结核分枝杆菌的抑制剂的合成和体外抗细胞活性

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摘要

A series of 4-aryl/alkylsulfonylmethylcoumarins have been synthesized and screened for in vitro antitubercular activity against Mycobacterium tuberculosis H 37Rv (MTB). Four of the compounds showed MIC in the range of 0.78-3.13 μg/mL proving their potential activity.

机译：已经合成了一系列4-芳基/烷基磺酰基甲基丙酮草并筛选用于对分枝杆菌H37RV（MTB）的体外抗细胞活性。四种化合物显示出MIC在0.78-3.13μg/ mL的范围内，证明其潜在的活性。

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《Bioorganic and Medicinal Chemistry Letters》 |2012年第14期|共3页
作者
JeyachandranM.; RameshP.; SriramD.; SenthilkumarP.; YogeeswariP.;
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作者单位

Post Graduate and Research Department of Chemistry Sri Paramakalyani College Alwarkurichi;

Department of Natural Products Chemistry School of Chemistry Madurai Kamaraj University Madurai;

Medicinal Chemistry and Antimycobacterial Research Laboratory Pharmacy Group Birla Institute of;

Medicinal Chemistry and Antimycobacterial Research Laboratory Pharmacy Group Birla Institute of;

Medicinal Chemistry and Antimycobacterial Research Laboratory Pharmacy Group Birla Institute of;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
4-Aryl/alkylsulfonylmethylcoumarins; Antitubercular activity; Mycobacterium tuberculosis;

机译：4-芳基/烷基磺酰基甲基丙酮草;抗核活性;结核分枝杆菌;

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1. Synthesis and in vitro antitubercular activity of 4-aryl/ alkylsulfonylmethylcoumarins as inhibitors of Mycobacterium tuberculosis [J] . JeyachandranM., RameshP., SriramD., Bioorganic and Medicinal Chemistry Letters . 2012,第14期

机译：4-芳基/烷基磺酰基甲基丙氨酸作为结核分枝杆菌的抑制剂的合成和体外抗细胞活性
2. Efficient synthesis and in vitro antitubercular activity of 1,2,3-triazoles as inhibitors of Mycobacterium tuberculosis. [J] . Shanmugavelan P, Nagarajan S, Sathishkumar M, Bioorganic and Medicinal Chemistry Letters . 2011,第24期

机译：1,2,3-三唑类作为结核分枝杆菌抑制剂的高效合成和体外抗结核活性。
3. Efficient synthesis and in vitro antitubercular activity of 1,2,3-triazoles as inhibitors of Mycobacterium tuberculosis. [J] . Shanmugavelan P, Nagarajan S, Sathishkumar M, Bioorganic and Medicinal Chemistry Letters . 2011,第24期

机译：1,2,3-三唑类作为结核分枝杆菌抑制剂的高效合成和体外抗结核活性。
4. The in vitro antagonistic activities of lactic acid bacteria against Mycobacterium avium subsp. paratuberculosis [C] . Donaghy JA, Totton NL, Rowe MT International Colloquium on Paratuberculosis . 2007

机译：乳酸菌对抗钙分枝杆菌的体外拮抗活性。 paratuberculosis.
5. Synthesis of Covalent Nitro Inhibitors of Mycobacterium tuberculosis Isocitrate Lyase [D] . You, Dai-Chi. 2020

机译：结核分枝杆菌异亚硝酸盐酶的共价硝基抑制剂的合成
6. Design synthesis and characterization of (1-(4-aryl)- 1H-123-triazol-4-yl)methyl substituted phenyl-6-methyl-2-oxo-1234-tetrahydropyrimidine-5-carboxylates against Mycobacterium tuberculosis [O] . Katharigatta N Venugopala, G B Dharma Rao, Subhrajyoti Bhandary, 2016

机译：（1-（4-芳基）-1H-123-三唑-4-基）甲基取代的苯基-6-甲基-2-氧-1234的设计合成和表征-四氢嘧啶-5-羧酸盐抗结核分枝杆菌
7. In vitro antitubercular activity of Tridax procumbens extracts against whole cell Mycobacterium tuberculosis and its lysine aminotransferase [O] . Thirunavukkarasu Rajasekar, Sivaraj Anbarasu, Manikkam Radhakrishnan, 2016

机译：Tridax procumbens提取物对全细胞结核分枝杆菌及其赖氨酸氨基转移酶的体外抗结核活性

Synthesis and in vitro antitubercular activity of 4-aryl/ alkylsulfonylmethylcoumarins as inhibitors of Mycobacterium tuberculosis

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