Bloodstream infections with OXA-23-producing Acinetobacter baumannii isolates in a university-affiliated hospital in Brazil: epidemiology and clinical outcomes.

摘要

Acinetobacter spp is a leading cause of nosocomial bacteremia. Carbapenems have been the drugs of choice for those infections. However, the emergence of carbapenem-hydrolyzing class D beta-lactamases has jeopardized the clinical usefulness of these antimicrobial agents. In Brazil, OXA-23-producing Acinetobacter baumannii (OXA-23-Ab) was first detected in 2003 in Curitiba, a southern region city, and rapidly spread to neighboring states. Since 2004, we have noticed a growing incidence of infections caused by IMP-1 -harboring carbapenem-resistant A baumannii in our, setting. However, OXA-23-Ab was detected for the first time in November 2006 in our hospital. We investigated the clinical outcomes of the initial patients with bloodstream infections caused by OXA-23-producing A baumannii during this outbreak in our setting.