Long-term effects of chronic radiation exposure on the level of somatic mutations in peripheral blood cells

摘要

The level of comatic mutations was studied at GPA locus and in the TCR system at late times since the onset to radiation exposure in persons exposed to chronic radiation accidents at the Mayak Production Association in the period 1949-1952. Individuals with predominantly external y-exposure and those with predominantly internal (mainly due to ~(90)Sr) exposures have been identified among the exposed population. The average dose to red bone marrow made up 121.5 cSv with individual values ranging from 11.0 to 462.7 cSv. An increased frequency of TCR-mutant lymphocytes was noted for exposed subjects. The level of GPA-variant erythrocytes of different types in the study group did not differ from the respective value registered in control. The analysis of TCR status showed no dependence of mutant cell frequence on exposure dose. The assumption is made that the rate of exposure dose and the nature of its formation (chronic exposure) exert a decisive influence on the level of somatic mutations in peripheral blood cells in humans.