Retinal Pigment Epithelium-Retina Transplantation for Retinal Degenerative Disease

摘要

IN THIS ISSUE OF THE JOURNAL, RADTKE AND ASSOCIATES report on the results of a phase 2 clinical trial of fetal retinal pigment epithelium (RPE)-retina transplants in patients with retinitis pigmentosa (RP) and age-related mac-ular degeneration (AMD). Visual acuity (VA) improved in seven of 10 study eyes and in three of 10 fellow control eyes. Some issues that merit consideration are: the study design, the basis of the visual improvement, the potential immunogenic-ity of the transplant, alternative approaches to retinal transplantation, and current challenges to further progress. Each of these issues is considered below