Synthesis and bioactivity of novel (γ-piperidono)dibenzo-33-aza-14-crown-3 ethers

摘要

Three-component reaction of polyether-linked bisnaphthaldehyde, ketone derivative, and ammonium acetate afforded seven new azacrown ethers containing γ-piperidone fragment with moderate yields. Most of the compounds were tested for their bioactivity. (3,5-Diethylpiperidono)azacrown ether showed significant cytotoxicity against Hep-G2, Lu1, RD,and MCF-7 cell lines. In addition, three of the synthesized azacrown ethers showed positive effect in antimicrobial test against Aspergillus niger.