Benzhydrylamines via Base-Mediated Intramolecular sp~3 C-Arylation of N-Benzyl-2-nitrobenzenesulfonamides-Advanced Intermediates for the Synthesis of Nitrogenous Heterocycles

摘要

N-Benzyl-2-nitrobenzcnesulfonamides underwent base-mediated intramolecular arylation at the benzyl sp~3 carbon to yield benzhydrylamines. The presence of electron withdrawing groups on the aromatic ring of the benzyl group was required to facilitate the C-arylation. Unsymmetrically substituted benzhydrylamines are advanced intermediates toward nitrogenous heterocycles, as exemplified in the syntheses of indazole oxides and quinazolines.